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      重磅免疫檢查點CTLA-4 (E2V1Z) Rabbit mAb上市 | CST 12月新品上市

      2021/12/23 14:02:03??????點擊:

      Dec. 2021

      熱門新產品

      CTLA-4 (E2V1Z) Rabbit mAb #53560

      貨號 規格 2021 年目錄價
      53560T
      20 μl ¥1,400.00
      53560S 100 μl ¥3,850.00 


      CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893

      貨號 規格 2021 年目錄價
      26893SF
      100 μg ¥7,400.00


      細胞毒性 T 淋巴細胞蛋白 4 (CTLA-4, CD152) 是 Ig 超家族的一員,能夠負向調控 T 細胞的早期激活 (1-4)。CTLA-4 蛋白主要在 T 細胞中表達,包括 CD8+ 細胞毒性 T 細胞、CD4+ 輔助 T 細胞和 CD4+/FoxP3+ 調節性 T 細胞(1,2)。CTLA-4 蛋白與 CD28 在細胞表面爭相結合 B7.1 (CD80) 和 B7.2 (CD86),導致 T 細胞活性下調 (5)。CTLA-4 下游 SHP-2 和 PP2A 的激活會減弱 TCR 信號轉導 (6)。研究表明,CTLA4 敲除小鼠患有引起過早死亡的淋巴組織增殖性疾病,表明 CTLA-4 可負向調控 T 細胞 (7)。相應 CTLA4 基因突變與多種疾病有關,包括胰島素依賴性糖尿病、格雷夫斯病、橋本甲狀腺炎、乳糜瀉、系統性紅斑狼瘡和 V 型自身免疫性淋巴細胞增殖性綜合征 (8,9)。其他研究表明,CTLA-4 阻滯是腫瘤免疫治療的有效策略 (10-12)。 


      CST CTLA-4 (E2V1Z) Rabbit mAb #53560 的重要性:CTLA-4 是免疫治療領域一個非常重要的轉化醫學相關靶點。研究人員需要觀察腫瘤組織微環境中該靶標的表達情況,以識別腫瘤微環境當中免疫細胞的表型和功能。CST CTLA-4 抗體(#53560)是目前市面上兩款用于 IHC-P應用的科研抗體之一,在十多種癌癥組織樣本當中進行了嚴格的驗證  (滑動查看下方驗證數據),適用于手動和基于自動染色機的免疫組化實驗,是性價比之選。


      同時,無載體配方CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893 也可以滿足包括質譜流式,成像質譜流式等各種需要特殊抗體偶聯的需求,是助力研究人員深入了解腫瘤免疫以及腫瘤微環境并開展轉化醫學研究的不二選擇。


      更多信息查看:CTLA-4 (E2V1Z) Rabbit mAb #53560CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893關鍵詞ECM, Extracellular matrix, collage, minor fibrillar collagen, bone and cartilage development
      12月新品列表 

      產品貨號

      產品名稱

      實驗應

      ?Adhesion / ECM
      63034S

      COL3A1 (E8D7R) XP? Rabbit mAb

      WB, IHC-P

      H

      74978S

      MUC5B (E4Y5Z) Rabbit mAb

      IHC-P, IF-IC

      H

      44454S

      MUC13 (E6Z1K) Rabbit mAb

      WB, IP, IHC-P, IF-IC

      H

      49536S

      PAI-1 (E3I5H) XP? Rabbit mAb

      WB, IHC-P

      H

      20302S

      Periostin (E5F2S) Rabbit mAb

      WB, IP, IHC-P

      H

      Apoptosis

      40618S Gasdermin E Antibody WB M, R
      88169S Mcl-1 (D2W9E) Rabbit mAb (Alexa Fluor? 594 Conjugate) IF-IC, F H, M, R
      66026S PARP (46D11) Rabbit mAb (Alexa Fluor? 488 Conjugate) F H, M, R, Mk
      53727S PARP (46D11) Rabbit mAb (Alexa Fluor? 594 Conjugate) F H, M, R, Mk
      34366S PARP (46D11) Rabbit mAb (Alexa Fluor? 647 Conjugate) F H, M, R, Mk
      58274S Phospho-RIP (Ser320) Antibody WB H

      Autophagy

      80158S

      CCPG1 (E3C5G) Rabbit mAb

      WB, IP

      H

      12074S Phospho-SQSTM1/p62 (Ser349) (E7M1A) Rabbit mAb (Alexa Fluor? 488 Conjugate) IF-IC, F H, M, (R)

      Ca, cAMP and Lipid Signaling

      37067S

      PhosphoPlus? PLCγ2 (Tyr759) Antibody Duet

      -

      -

      Cell Cycle / Checkpoint Control

      99274S

      Phospho-Rb (Ser807) Antibody

      WB

      H

      76998S

      XRCC1 (E4A3V) XP? Rabbit mAb

      WB, IP, IHC-P, IF-IC

      H, M, R

      Chromatin Regulation / Nuclear Function

      50607S

      FTSJ3 (E6T9J) Rabbit mAb WB H, M

      20123S

      Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor? 555 Conjugate)

      F

      H, M, R, Mk, (X, Z)

      10584S

      Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor? 594 Conjugate)

      F

      H, M, R, Mk, (X, Z)

      88197C FastScan? LbCpf1 (Strain ND2006) ELISA Kit ELISA -

      34907S

      MLL1 (E9W9Z) Rabbit mAb (Carboxy-terminal Antigen)

      WB, IP, ChIP

      H, Mk

      79030S

      TIF1α/TRIM24 (E9T3N) Rabbit mAb

      WB, IP, IHC-P

      H, M, R, Mk

      92145S

      TTF-I Antibody

      WB

      H, M, R, Mk

      Cytoskeletal Signaling

      47610S KIF5B (E3H4J) Rabbit mAb WB, IF-IC H, M, R
      62696S KIF5B (E4A5A) Rabbit mAb WB, IP, IF-IC H
      47293S SETD3 Antibody WB, IP H, Mk
      37430S ZNF185 (E6W4I) Rabbit mAb WB, IP, IF-IC H
      86942S ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor? 488 Conjugate) IF-IC H, Mk
      98225S ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor? 647 Conjugate) IF-IC H, Mk

      Developmental Biology

      64022S

      CD15/SSEA1 (MC480) Mouse mAb (Alexa Fluor? 488 Conjugate)

      IF-IC, F

      M

      16274S

      ETV5 (E5G9V) Rabbit mAb

      WB, IP

      H, M

      54319S

      Human FGF-9 Recombinant Protein

      -

      -

      74356S

      Mouse FGF-9 Recombinant Protein

      -

      -

      41560S

      HIF-1α (D1S7W) XP? Rabbit mAb (Biotinylated)

      WB

      H, M, Mk

      70948S

      Notch2 (D76A6) XP? Rabbit mAb (Alexa Fluor? 488 Conjugate)

      IF-IC, F

      H, M, R

      36135S

      POU2F3 (E5N2D) XP? Rabbit mAb

      WB, IHC-Bond, IHC-P

      H

      18113S

      RUNX3/AML2 (E8D5W) XP? Rabbit mAb

      WB, IP, IHC-P

      H

      44909S

      Human TGF-α Recombinant Protein

      -

      -

      10179S

      YAP/TAZ (D24E4) Rabbit mAb (Alexa Fluor? 647 Conjugate)

      F

      H, M, Mk

      Glucose / Energy Metabolism

      66933S GPAT4 Antibody WB H

      Immunology and Inflammation

      81123S ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor? 555 Conjugate) F M
      29956S ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor? 594 Conjugate) F M
      90776S Bcl-3 (E2M6N) Rabbit mAb WB, F H
      16611S Bcl-3 (E4D4K) Rabbit mAb WB, IP, IHC-P H, M
      64137S Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (Alexa Fluor? 647 Conjugate) F H
      16803S Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (PE Conjugate) F H
      88083S CD3ζ Antibody WB H, M
      23578S CD27 Antibody WB M
      26233S CD34 (E2J1K) Rabbit mAb WB, IF-F, IF-IC M
      46894S CD37 (E4K2M) Rabbit mAb WB, IP, F H
      55084S CD74 (D5N3I) XP? Rabbit mAb (PE Conjugate) F H
      89660S Phospho-CD79A (Tyr210) (E8E9Z) Rabbit mAb WB, F H
      57950S CLEC12A/CLL-1 (E5T5V) Rabbit mAb WB, IP, F H

      53560S

      CTLA-4 (E2V1Z) Rabbit mAb

      WB, IP, IHC-Bond, IHC-P

      H, M

      26893SF

      CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) 

      WB, IHC

      H, M

      87223S DPEP-1/MDP (E4O6J) XP? Rabbit mAb WB, IHC-P, IF-IC H
      76290S DPEP-1/MDP (E5C2V) Rabbit mAb WB, IF-IC H
      78401S FcRγ (E6Y1A) Rabbit mAb WB, IP, IHC-Bond, IHC-P, IF-F, IF-IC H, M
      20085S FcRn (E4D5I) Rabbit mAb WB, IHC-P M, R
      45850S Fibrinogen gamma chain (E1U3Z) XP? Rabbit mAb WB, IHC-Bond, IHC-P H
      89572S Galectin-3/LGALS3 (E7B6R) Rabbit mAb WB, IP, IHC-P, IF-F, IF-IC H, M, R
      99695S Granzyme H (E3H7W) Rabbit mAb WB, F H
      61606S HPK1 (E1C3L) Rabbit mAb (Biotinylated) WB H
      18526S IL-2Rγ (E2Z5W) Rabbit mAb WB, IP, F M
      57529S Human IL-11 Recombinant Protein - -
      76561S Mouse IL-11 Recombinant Protein - -
      68350S Integrin α11 Antibody WB, IP H
      98344S IRF-8 (E8X4K) Rabbit mAb WB, IP, IF-F, IF-IC, F, ChIP H, M, R
      51817S ITK (E4X7M) Rabbit mAb (Biotinylated) WB H

      89368S

      LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor? 488 Conjugate)

      IF-F, IF-IC

      M

      73294S LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor? 594 Conjugate) IF-F, IF-IC M
      98215S MSR1 (E7P6W) Rabbit mAb IHC-P M
      10054S NEK7 Antibody WB H, M
      96874S Phospho-NF-κB p65 (Ser529) Antibody WB H
      84223T Human Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit - -
      97624T Mouse Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit - -

      73582C

      PathScan? Phospho-Stat1 (Tyr701) Sandwich ELISA Kit ELISA H, M
      73452S Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb (Alexa Fluor? 555 Conjugate) F H, M, R, Mk, (Hm, B, Pg, Hr)
      61958S Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb (Alexa Fluor? 594 Conjugate) F H, M, R, Mk, (Hm, B, Pg, Hr)
      72337S TNF-R2 (E8D7P) Rabbit mAb WB, IP, F H
      38519S Toll-like Receptor 4 (E5D8T) Rabbit mAb WB H
      58125S Tox (E5J8A) Rabbit mAb IF-IC, F H

      Infectious Diseases

      74698S SARS-CoV-2 Envelope Protein Antibody WB Vir
      37393C PathScan? SARS-CoV-2 Nucleocapsid Protein Sandwich ELISA Kit ELISA Vir
      34340S SARS-CoV-2 ORF3a Antibody WB, IP Vir

      MAP Kinase Signaling

      40737S

      MEK5 (E4C4B) Rabbit mAb WB, IP H, M, R

      Metabolism

      58662S

      AGK Antibody WB H
      24972S AIFM2/FSP1 Antibody WB H
      31219S COX2/MT-CO2 Antibody WB, IP H, Mk
      26381S DHODH (E9X8R) Rabbit mAb WB H, M, R
      17412S MT-ATP8 Antibody WB, IP H
      45535S Perilipin-2 Antibody WB, IP H
      65675S TOM70 Antibody WB H, M, R
      53370S Xanthine Dehydrogenase/Oxidase Antibody WB H

      Motif Antibodies

      46784S

      PTMScan? HS Acetyl-Lysine Motif (Ac-K) Kit

      -

      -

      Neuroscience

      56161C

      PathScan? β-Amyloid (1-40) Sandwich ELISA Kit

      ELISA

      H

      49285S

      ApoE (E7X2A) Rabbit mAb

      WB, IP, IHC-P, IF-F, IF-IC

      M

      80718S DNAJC7 Antibody WB H, M, R
      90963S Neurexin-3 Antibody WB H, M, R

      51510T

      α-Synuclein (E4U2F) XP? Rabbit mAb

      WB, IP, IHC-P, IF-F, IF-IC

      H, M, R

      98863T

      TREM2-dependent mTOR Metabolic Fitness Antibody Sampler Kit

      -

      -

      RTK

      96453S Phospho-Axl (Tyr779) Antibody WB, IP H
      76799S HER2/ErbB2 (CB11) Mouse mAb IHC-Bond, IHC-P H

      Translational Control

      41025S ADAR1 (E6X9R) XP? Rabbit mAb (Alexa Fluor? 488 Conjugate) IF-IC, F H, Mk
      31358S

      DIMT1 Antibody

      WB

      H, M, R, Mk

      Ubiquitin and Ubiquitin-like proteins

      17579S PSMB10/MECL-1 (E6R7O) Rabbit mAb WB H, M

      Related Products

      20533S

      10% SDS Solution

      C&R

      -

      5708S Anti-biotin (D5A7) Rabbit mAb (Alexa Fluor? 488 Conjugate) F All

      7005S

      Glycine Solution (10X)

      ChIP, C&R

      -

      20664S His-Tag (D3I1O) XP? Rabbit mAb (Alexa Fluor? 555 Conjugate) IF-IC, F All
      81940S His-Tag (D3I1O) XP? Rabbit mAb (Alexa Fluor? 594 Conjugate) IF-IC, F All
      67476S V5-Tag (D3H8Q) Rabbit mAb (Sepharose? Bead Conjugate) IP All
      83862S V5-Tag (E9H8O) Mouse mAb (Sepharose? Bead Conjugate) IP All

      參考文獻:

      1. Brunet, J.F. et al. (1988) Immunol Rev 103, 21-36.

      2. Brunet, J.F. et al. (1987) Nature 328, 267-70.

      3. Dariavach, P. et al. (1988) Eur J Immunol 18, 1901-5.

      4. Linsley, P.S. (1995) J Exp Med 182, 289-92.

      5. Collins, A.V. et al. (2002) Immunity 17, 201-10.

      6. Rudd, C.E. et al. (2009) Immunol Rev 229, 12-26.

      7. Waterhouse, P. et al. (1995) Science 270, 985-8.

      8. Romo-Tena, J. et al. (2013) Autoimmun Rev 12, 1171-6.

      9. Wang, J. et al. (2014) PLoS One 9, e85982.

      10. Egen, J.G. et al. (2002) Nat Immunol 3, 611-8.

      11. Hodi, F.S. et al. (2003) Proc Natl Acad Sci U S A 100, 4712-7.

      12. Pardoll, D.M. (2012) Nat Rev Cancer 12, 252-64.

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